论文部分内容阅读
通过拉曼光谱和红外光谱法分析维生素C包合物,探讨拉曼光谱法作为一种新的验证包合物形成方法的可行性。采用饱和水溶液法制备维生素C包合物,共焦拉曼光谱仪和傅里叶转换红外光谱仪分别测定并获得β-环糊精、维生素C、维生素C与β-环糊精物理混合物及其包合物四种固体粉末的拉曼图谱和红外图谱并将其进行对照分析。拉曼图谱和红外图谱共同证明了维生素C通过氢键作用嵌入β-环糊精的疏水空腔形成包合物,从而增加了它的稳定性。拉曼光谱法具有快速、准确、简便、无损测量等显著优势,可作为验证药物包合物的形成重要手段。
The vitamin C inclusion complex was analyzed by Raman spectroscopy and infrared spectroscopy to explore the feasibility of Raman spectroscopy as a new method to verify the formation of inclusion complex. The vitamin C inclusion complex was prepared by saturated aqueous solution method, the confocal Raman spectrometer and the Fourier transform infrared spectrometer were used to determine and obtain the physical mixtures of β-cyclodextrin, vitamin C, vitamin C and β-cyclodextrin, respectively Raman and IR spectra of four solid powders were compared and analyzed. Raman spectroscopy and infrared spectroscopy have shown that vitamin C enhances its stability by hydrogen bonding to the hydrophobic cavity of β-cyclodextrin to form an inclusion complex. Raman spectroscopy has the obvious advantages of rapid, accurate, simple and nondestructive measurement, which can be used as an important method to verify the formation of drug inclusion.