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观察中发现,在有 Down 氏综合征妊娠史的妇女甲状腺肿和甲状腺疾病常多于未患该征的妇女。为此,Fialkow 等(1965)从148例有 Down 氏综合征史的妇女及相同例数的以年龄配对对照妇女测定血清甲状腺抗体。高抗体滴定度在病例组明显高于对照组,统计学有显著意义。作者并总结了其它类似的10个研究,除2个外均证实这一观察。作者认为如果在妊娠期及其以后的数年中母体血清甲状腺抗体与 Down 氏综合征之间的这种联系存在,就有可能成为对该征产前筛查的有用基础。为了研究这种可能性,作者进行一项用贮存血清在孕中期的研究。
Observations found that women with Down’s syndrome pregnancy history goiter and thyroid disease often more than women without this sign. To do this, Fialkow et al. (1965) measured serum thyroid antibodies from 148 women with a history of Down’s syndrome and the same age-matched control women. High antibody titer in the case group was significantly higher than the control group, statistically significant. The authors summed up 10 other similar studies, all of which confirmed this observation except for two. The authors conclude that if this link between maternal serum thyroid antibodies and Down’s syndrome is present during pregnancy and beyond, it could become a useful basis for pretrial screening. To investigate this possibility, the authors conducted a study in the second trimester of the use of stored serum.