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目的:探讨二甲双胍联合益气补血法对2型糖尿病合并糖尿病肾病患者HGF、肌酐清除率及临床疗效的影响。方法:回顾性研究我院2型糖尿病合并糖尿病肾病患者120例,按照就诊先后顺序分为实验组和对照组,每组各60例,对照组患者采取二甲双胍治疗,实验组患者采取二甲双胍联合益气补血法进行治疗。比较治疗前后两组患者血清肝细胞生长因子(Hepatocyte growth factor,HGF)、血清胱抑素C(Cystatin C)、转化生长因子-β1(Transforming growth factor-β1,TGF-β1)、血清肌酐(Serum creat imine,SCr)、血尿素氮(Blood urea nitrogen,BUN)、肌酐清除率(Serum creat inine clearance rate,Ccr)及24 h尿蛋白定量(24 h Upro)水平变化,同时比较治疗结束后两组临床疗效。结果:与治疗前相比,两组患者的HGF、Ccr显著升高,TGF-β1、Cys C、Scr、BUN及24 h Upro显著降低(P<0.05);治疗结束后与对照组相比,实验组患者HGF水平较高(P<0.05);Cys C、TGF-β1水平较低(P<0.05);SCr、BUN、24 h Upro水平较低(P<0.05);Ccr水平较高(P<0.05)。结论:二甲双胍联合益气补血法能够提高2型糖尿病合并糖尿病肾病的临床疗效,推测其机制可能与降低Cys C、TGF-β1、SCr、BUN、24 h Upro水平,提高HGF、CCr水平有关。
Objective: To investigate the effect of metformin combined with invigorating qi on patients with type 2 diabetes and diabetic nephropathy HGF, creatinine clearance rate and clinical effect. Methods: A retrospective study of 120 patients with type 2 diabetes mellitus and diabetic nephropathy in our hospital was divided into experimental group and control group according to the order of treatment, 60 cases in each group and metformin in control group. Patients in experimental group were treated with metformin combined with Qi Blood therapy for treatment. The levels of serum HGF, Cystatin C, Transforming growth factor-β1 (TGF-β1) and serum creatinine (Serum creatinine (SCr), blood urea nitrogen (BUN), serum creatinine clearance rate (Ccr) and 24 h urinary protein (24 h Upro) Clinical efficacy. Results: Compared with those before treatment, the levels of HGF and Ccr were significantly increased and the levels of TGF-β1, Cys C, Scr, BUN and 24 h Upro were significantly decreased in both groups (P <0.05). Compared with the control group, The level of HGF in experimental group was higher (P <0.05), the level of Cys C and TGF-β1 was lower (P <0.05), the level of SCr and BUN was lower in 24 h (P <0.05) <0.05). CONCLUSION: Metformin combined with qi and nourishing blood can improve the clinical curative effect of type 2 diabetes mellitus with diabetic nephropathy. The mechanism may be related to decreasing the levels of Cys C, TGF-β1, SCr, BUN and 24 h Upro and increasing the levels of HGF and CCr.