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目的:制备盐酸青藤碱壳聚糖纳米粒,并考察其性质和体外释药特性。方法:通过微乳液-离子交联法制备盐酸青藤碱壳聚糖纳米粒,考察纳米粒的形态、粒径和zeta电位,紫外分光光度法测定其载药量和包封率,透析法研究其体外释药特性。结果:制得的纳米粒呈球形或类球形,平均粒径为98.3nm,包封率为67.2%,体外模拟释药结果表明载药纳米粒药物释放速率在24h内持续稳定。结论:微乳液-离子交联法制备盐酸青藤碱壳聚糖纳米粒简便可靠,体外释药具有明显的缓释作用。
Objective: To prepare sinomenine hydrochloride chitosan nanoparticles and study its properties and in vitro release characteristics. Methods: Sinomenine chitosan nanoparticles were prepared by microemulsion-ionic crosslinking method. The morphology, particle size and zeta potential of the nanoparticles were investigated. The drug loading and entrapment efficiency were determined by UV spectrophotometry. Its in vitro release characteristics. Results: The prepared nanoparticles were spherical or spheroidal, the average particle size was 98.3nm, the entrapment efficiency was 67.2%. The in vitro release results showed that the sustained release rate of drug-loaded nanoparticles sustained within 24h. CONCLUSION: Sinomenine chitosan nanoparticles prepared by microemulsion-ion crosslinking method are simple and reliable, and have a sustained release effect in vitro.