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骨髓间充质干细胞(marrow mesenchymal stem cells,MSCs)是一种多能干细胞,具有自我更新和多向分化的能力。MSCs治疗缺血性心脏病可能机制包括直接分化为心肌细胞、血管内皮细胞及旁分泌等机制。其中目前研究最多的旁分泌机制主要表现为促进新生血管生成、抗心肌细胞凋亡、趋化其他细胞参与心肌修复等三个方面。
Bone marrow mesenchymal stem cells (MSCs) are pluripotent stem cells that have the ability to self-renew and differentiate into multiple directions. The possible mechanisms of MSCs in treating ischemic heart disease include direct differentiation into cardiomyocytes, vascular endothelial cells and paracrine mechanisms. One of the most studied paracrine mechanism mainly for the promotion of angiogenesis, anti-myocardial cell apoptosis, chemotaxis and other cells involved in myocardial repair in three areas.