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目的:探讨一氧化氮(NO)在戊四唑癫痫发病机制中的作用.方法:每天注射戊四唑建立大鼠癫痫模型,测定癫痫发作后大鼠大脑皮质、海马一氧化氮(NO)和一氧化氮合酶(NOS)活性变化.结果:癫痫发作后海马NO含量和NOS活性显著升高(P＜0.01).结论:NO在戊四唑诱导的癫痫中具有致痫性.“,”Aim:To explore the pathogenetic role of nitric oxide(NO) in pentylenetetrazol-induced seizures. Method:Epileptic model was induced in rats by daily injection of pentylenetetrazol. The changes in NO concentration and nitric oxide synthase (NOS)activity in cerebral cortex and hippocampus after seizures were measured. Result:The NO content and the NOS activity were increased significanly in hippocampus after seizures. Conclution:NO might result in seizures in pentylentetrazol-induced seizures.