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采用聚合酶链反应 单链构象多肽性分析法 (PCR SSCP)及HP尿素酶快速检测法 ,随机对 4 6例慢性浅表性胃炎、39例慢性萎缩性胃炎、39例胃溃疡、36例胃癌的胃粘膜活检标本进行了ras、p16、p5 3及HP检测 ,并对其在胃癌致癌机制中的相互关系进行研究。结果表明 ,①ras及p5 3在胃癌标本中的检出率明显高于萎缩性胃炎、胃溃疡及浅表性胃炎 (P <0 0 5 ) ;② p16在胃癌标本中的检出率远远低于基本正常胃粘膜及其他胃良性病变 (P<0 0 5 ) ;③HP在胃癌标本中的检出率明显高于萎缩性胃炎、胃溃疡及浅表性胃炎 (P <0 0 5 ) ;④ras和p5 3阳性表达的各种胃良、恶性疾病中的HP阳性检出率均高于p16阳性表达的各种胃良、恶性疾病中的HP阳性检出率(P <0 0 5 )。提示ras、p5 3、p16和HP感染在胃癌致病机制中可能具有重要作用 ,并可能有相互协同作用
Using polymerase chain reaction single-strand conformation polymorphism assay (PCR-SSCP) and HP urease rapid assay, randomly selected 46 patients with chronic superficial gastritis, 39 patients with chronic atrophic gastritis, 39 patients with gastric ulcer, and 36 patients with gastric cancer Gastric mucosal biopsy specimens were tested for ras, p16, p53, and HP, and their correlations in gastric cancer carcinogenesis were studied. The results showed that the detection rates of 1ras and p53 in gastric cancer specimens were significantly higher than atrophic gastritis, gastric ulcer, and superficial gastritis (P < 0.05); 2 The detection rate of p16 in gastric cancer specimens was far lower The detection rate of 3HP in gastric cancer specimens was significantly higher than that of atrophic gastritis, gastric ulcer, and superficial gastritis (P < 0.05); 4ras The positive rate of HP positive in various gastric benign and malignant diseases with p53 positive expression was higher than that in various gastric benign and malignant diseases with positive p16 expression (P < 0.05). It is suggested that ras, p53, p16 and HP infections may play an important role in the pathogenesis of gastric cancer and may have synergistic effects.