论文部分内容阅读
目的:探讨难治性急性淋巴细胞白血病化疗的可行方案。方法:回顾性分析1例经历13个月治疗未缓解的合并有肺结核的难治性急性淋巴细胞白血病最终获得完全缓解患者的临床资料,结合国内外相关文献,探讨其获得缓解的可能原因。结果:患者先行抗结核治疗4周,再行VDCP、VMCP等方案诱导治疗未获缓解,13个月后大剂量MTX联合培门冬酶化疗后获完全缓解。结论:培门冬酶在成人难治性急性淋巴细胞白血病中的作用值得肯定;重症感染、成分输血等是白血病自发缓解的可能因素;自发缓解后仍需进一步治疗。
Objective: To investigate the feasibility of chemotherapy for refractory acute lymphoblastic leukemia. Methods: A retrospective analysis was conducted on the clinical data of 1 patient with refractory acute lymphoblastic leukemia complicated with pulmonary tuberculosis who did not undergo remission after 13 months of treatment. The possible causes of remission were discussed in combination with relevant literatures at home and abroad. Results: Patients were treated with antituberculous therapy for 4 weeks. Induction therapy such as VDCP and VMCP was not relieved. After 13 months, the patients were completely relieved by high dose MTX combined with pegasys. Conclusions: The role of pegaspargase in adult refractory acute lymphoblastic leukemia is worthy of recognition. Severe infection and component transfusion are the possible causes of spontaneous remission of leukemia. However, further treatment is needed after spontaneous remission.