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为了研究先天性心脏阻滞与其母亲能通过胎盘的抗体之间的关系,本文用免疫荧光检测技术,检查了41名患儿母亲和8名患儿的血清中抗胎儿心脏组织抗体,50例正常母亲做对照。作者还采用了免疫过氧化酶染色法,检查了2例先天性心脏完全阻滞患儿的心脏组织内的免疫球蛋白的沉淀物和补体成份。结果血清学所见,母亲血清与胎儿心脏组织的免疫荧光显微镜检查所见:在孤立性先天性心脏阻滞41例婴儿母亲中,有21例免疫荧光反应阳性,占51%(其中IgG全部阳性,IgM仅2例阳性);对照组94人次,只有9人次阳性(占10%,P<0.01)其中
In order to study the relationship between congenital heart block and its mothers’ ability to pass through the placenta, we examined the anti-fetal cardiomyocyte antibodies in 41 mothers and 8 infants by immunofluorescence. Fifty normal Mother to control. The authors also used immunoperoxidase staining to examine the presence of immunoglobulin precipitates and complement components in the heart tissue of 2 children with congenital heart defects. Results Serological findings, immunofluorescence microscopy of the mother’s serum and fetal heart tissue showed that in 41 cases of isolated mothers with congenital heart block, 21 were positive for immunofluorescence, accounting for 51% (of which IgG was all positive , IgM only 2 positive); control group of 94 people, only 9 were positive (10%, P <0.01)