论文部分内容阅读
自从1908年Schauenstein首先提出原位癌的定义,1919年Tames Ewing报道乳腺的“前恶性”病变,1949年Papanicolaou提出异型增生的概念后,文献中不断有癌前病变的报道。由于研究手段的局限性,大多数文章从形态学改变与临床随访的角度提出异型增生、异型化生可能是癌前病变并认为与原位癌、微小浸润癌的发生有联系。近十多年来,人们不断采用新的方法来研究癌前病变。有人曾将染色体技术用于异型增生和原位癌的研究;但是染色体技术有赖于细胞分裂象的存在,在探讨癌前病变方面受到了一定的限制。利用显微分光光度仪,对间期肿瘤细胞的
Since Schauenstein first proposed the definition of carcinoma in situ in 1908, Tames Ewing in 1919 reported “premalignant” lesions of the mammary gland and Papanicolaou proposed the concept of dysplasia in 1949, there have been reports of precancerous lesions in the literature. Due to the limitations of research methods, most articles suggest dysplasia from morphological changes and clinical follow-up. Anomalous metaplasia may be a precancerous lesion and is considered to be associated with the occurrence of carcinoma in situ and minimal invasive cancer. For more than a decade, people continue to adopt new methods to study precancerous lesions. Chromosome technology has been used for dysplasia and carcinoma in situ research; but chromosome technology depends on the existence of cell division, in the study of precancerous lesions has been subject to certain restrictions. Using a spectrophotometer, the cells of the interphase were collected