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目的 探讨雷公藤多甙治疗对成人隐匿性自身免疫性糖尿病 (LADA)早期患者胰岛β细胞功能及免疫学指标的影响。方法 把 18例患者随机分为两组 ,试验组 (n =9)用雷公藤多甙加口服降糖药 ,对照组 (n =9)仅口服降糖药。结果 与对照组比较 ,6个月后试验组餐后血糖降低 ,餐后 C肽上升 ,CD+4细胞下降 (P <0 0 5 ) ;而 3个月 CD+4 CD+8降低 (P <0 0 5 )。 试验组有 2例 ICA(阳性 )转阴 ,对照组无一例转阴 (P <0 0 5 )。 ΔCP与 CD+4 CD+8呈负相关(P <0 0 5 )。结论 初步提示雷公藤多甙对 LADA早期患者细胞免疫有调节作用 ,可在短期内降低胰岛细胞抗体水平 ,有改善胰岛 β细胞功能的趋势。
Objective To investigate the effects of tripterygium glycosides on islet β-cell function and immunological parameters in patients with latent autoimmune diabetes (LADA) in adults. Methods 18 patients were randomly divided into two groups. The experimental group (n = 9) received tripterygium glycosides plus oral hypoglycemic agents and the control group (n = 9) received oral hypoglycemic agents only. Results Compared with the control group, after 6 months, the postprandial blood glucose, postprandial C peptide and CD + 4 cells in the experimental group decreased (P <0.05), while the CD + 4 CD + 8 levels in the experimental group decreased 3 months (P < 0 0 5). In the test group, 2 cases of ICA (positive) turned negative while none of the control group turned negative (P <0 05). ΔCP was negatively correlated with CD + 4 CD + 8 (P <0 05). Conclusions Preliminary results suggest that Tripterygium glycosides can modulate cellular immunity in patients with LADA in the early stage and reduce the level of islet cell antibodies in the short term, which may improve the function of pancreatic β cells.