创伤性脑损伤患者常可发生一系列代谢紊乱,其中一个显著的特征是胰岛素抵抗(IR)。创伤性脑损伤后发生严重的IR可使机体供能减少,高血糖持续存在,影响颅脑损伤患者的预后。颅脑损伤后IR的发病机制尚未阐明,现对颅脑损伤后IR的发生机制及其影响因素的研究进展进行综述。 Traumatic brain injury patients often occur a series of metabolic disorders, one of the notable features is insulin resistance (IR). Severe IR after traumatic brain injury can reduce the body’s energy supply, hyperglycemia persists, affecting the prognosis of patients with brain injury. The pathogenesis of IR after craniocerebral injury has not been elucidated yet. The research progress of the pathogenesis of IR after craniocerebral injury and its influencing factors are reviewed.