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目的 :研究谷胱甘肽S转移酶 π(GST π)mRNA在胃癌、大肠癌及其相邻正常组织中的表达 ,明确GST π在胃癌、大肠癌发生、发展及自主性耐药中的作用。方法 :采用RT PCR方法 ,检测 42例胃癌、3 4例大肠癌及其相邻正常组织中GST πmRNA的表达。结果 :GST πmRNA在胃癌和大肠癌组织中的表达分别为 3 8.1%和41.2 % ,明显高于其相邻正常组织中的表达 (P <0 .0 5)。结论 :GST πmRNA表达与胃肠癌发生、发展及内在性耐药有关
Objective: To study the expression of GST π mRNA in gastric cancer, colorectal cancer and its adjacent normal tissues and to clarify the role of GST π in gastric cancer, colorectal cancer occurrence, development and independent drug resistance . Methods: The expression of GST πmRNA in 42 cases of gastric carcinoma, 34 cases of colorectal carcinoma and adjacent normal tissues was detected by RT-PCR. Results: The expression of GST π mRNA in gastric cancer and colorectal cancer tissues was 31.1% and 41.2%, which was significantly higher than that in adjacent normal tissues (P <0.05). Conclusion: The expression of GST πmRNA is associated with the occurrence, development and intrinsic resistance of gastrointestinal cancer