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目的探讨甲型H1N1流感患者病程初期血清补体C3、C4和CH50的变化及临床意义。方法采用免疫透射比浊法及脂质体免疫测定法分别检测369例轻症甲型H1N1流感(轻症组)和23例重症甲型H1N1流感(重症组)患者病程5d内血清中补体C3、C4水平及总补体活性(CH50)。结果轻症组C3值为(1.10±0.18)g/L,重症组为(1.10±0.19)g/L;轻症组C4值为(0.29±0.08)g/L,重症组为(0.29±0.08)g/L;76%的患者病程早期CH50出现轻微上升,15%出现明显下降;轻症组CH50值为(48.84±19.38)U/ml,重症组为(57.48±13.25)U/ml(P=0.036)。结论甲型H1N1流感患者病程早期血清C3和C4水平均在正常较高水平,CH50多轻微上升,部分明显下降。重症甲型H1N1流感CH50水平较轻症升高,有一定预警意义。
Objective To investigate the changes and clinical significance of serum complement C3, C4 and CH50 in patients with early stage of H1N1 influenza. Methods Immuno-turbidimetry and lipofection immunoassay were used to detect the levels of serum complement C3, serum creatinine in 369 patients with mild type A (H1N1) and 23 patients with severe type A (H1N1) C4 level and total complement activity (CH50). Results The values of C3 were (1.10 ± 0.18) g / L in mild disease group and (1.10 ± 0.19) g / L in severe disease group, and (0.29 ± 0.08) g / L in mild disease group and (0.29 ± 0.08) ), and the CH50 increased slightly in 15% of the patients in the course of disease. The CH50 of the mild group was (48.84 ± 19.38) U / ml and that of the severe group was (57.48 ± 13.25) U / ml = 0.036). Conclusions Serum levels of C3 and C4 in early stage of H1N1 influenza patients are at normal high levels, with a slight increase in CH50 and some decrease. Severe influenza A H1N1 influenza CH50 levels increased mild, there is a warning.