氧哌羟苯唑头孢菌素(Cefoperazone)为一第三代头孢菌素,抗菌谱广,抗菌作用强和体内分布良好。本文报道本品(太原制药厂生产)的LD_(50),安全性试验,降压试验和热原试验等毒性研究结果以及本品在健康家兔组织和体液中的分布情况。 1.毒性研究结果:经尾静脉注射本品对雄性和雌性小白鼠的LD_(50)分别为4430.04±326.12和4872.86±458.13mg/kg,两者无 Cefoperazone is a third-generation cephalosporin with broad antibacterial spectrum, strong antibacterial activity and good in vivo distribution. This article reports the LD_ (50), safety test, hypotensive test and pyrogen test of this product (produced by Taiyuan Pharmaceutical Factory) and other toxicological studies as well as the distribution of this product in healthy rabbit tissues and body fluids. 1. Toxicity study results: The LD_ (50) of the product injected through tail vein in male and female mice were 4430.04 ± 326.12 and 4872.86 ± 458.13mg / kg, respectively