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对氯苯氧乙酸盐为一种植物生长调节剂,近年来常用于防止瓜果的落花落果,形成无仔果实,其应用较广。它属于低毒类物质,大鼠径口LD_(50)为2000mg/kg,小鼠为794mg/kg。 本品之遗传毒性问题,口内外均未见报道,但其同系物2,4-D类在诱变问题上近年来国外有争论,特别是seiler等的研究中提出2,4-D类可能具有生殖毒性。他还引用了Magnusson等的报告叙述用2,4-D类喂养果蝇15天左右可出现伴性隐性致死试验之阳性结果,但本品较2,4-D类少一个氯,并增加一个钠盐,就可增加其降解速度,减少在体内的蓄积性。为阐明对氯苯氧乙酸盐对雄性生殖系统的毒性以及诱变性问题,我们进行了小鼠精子畸形试验,睾丸体比的变化,以及睾丸组
Parachlorophenoxyacetate is a plant growth regulator, in recent years commonly used to prevent the fall of fruits and vegetables, the formation of Aberdeen fruit, the wider application. It is a low-toxic substance, rat diameter LD_ (50) of 2000mg / kg, mice 794mg / kg. Genotoxicity of this product, both inside and outside the mouth have not been reported, but its homologue 2,4-D class in the mutagenesis issue abroad in recent years have been controversial, especially seiler and other research proposed 2,4-D may Reproductive toxicity. He also cited the report by Magnusson et al. That the positive results of the associated recessive lethality test may occur in Dairy 2,4-D fed birds for about 15 days but this product is one less chlorine than that of 2,4-D and increases A sodium salt, can increase its rate of degradation, reduce the accumulation in the body. To elucidate the toxicity and mutagenicity of p-chlorphenoxyacetate to the male reproductive system, we performed mouse sperm abnormality tests, changes in testicular body mass ratio, and testis