论文部分内容阅读
采用灌服茯苓煎剂的方法，观察了小白鼠灌服茯苓煎剂以后，心肌对哇巴因敏感性的改变和心肌Ｋ＋含量的变化。实验结果显示，灌服茯苓煎剂以后，小白鼠对哇巴因的敏感性增加，对照组哇巴因致死量为１６．２０±２．３２ｕｇ／ｇ体重，茯苓组为１２．４７±２．３１ｕｇ／ｇ体重（Ｐ＜０．０５）。心肌组织Ｋ＋含量测定显示茯苓增加正常心肌的Ｋ＋含量。空白对照组干燥心肌Ｋ＋含量为５．３６±２．１１ｐｐｍ／ｍｇ，而茯苓组为６．９５±１．９８ｐｐｍ／ｍｇ。（Ｐ＜０．０５）。实验结果提示茯苓可能对细胞内Ｋ＋含量有调控作用。其机制可能是通过增加Ｎａ＋—Ｋ＋ＡＴＰ酶活性而实现。
Using the method of gavage of Poria decoction, the change of myocardium sensitivity to ouabain and the change of myocardial K + content were observed after mice taking Poria decoction. The experimental results showed that after oral administration of Poria decoction, the sensitivity of mice to ouabain increased. The lethal dose of ouabain in control group was 16.20 ± 2.32ug / g body weight and that of Poria group was 12.47 ± 2. 31 ug / g body weight (P <0.05). Measurement of K + content in myocardium showed that Poria cocos + increased the content of K + in normal myocardium. The K + content of dry myocardium in blank control group was 5.36 ± 2.11ppm / mg, while that in Poria group was 6.95 ± 1.98ppm / mg. (P <0.05). Experimental results suggest that Poria may regulate the intracellular K + content. The mechanism may be achieved by increasing Na + -K + ATPase activity.