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[Objective] To study the effects of FRUCTUS SCHISANDRAE CHINENSIS on the hepatic antioxidant system and trace elements in mice.[Methods] 40 male ICR mice were randomly divided into control group,low dose group,middle dose group and high dose group.Intragastric administration for 4 weeks,and then the content of reduced glutathione(GSH),malondialdehyde(MDA) and superoxide dismutase(SOD) in the hepatic tissue were determined.The hepatic tissue was digested by HNO3-HClO4 mixed acid,and the contents of Zn,Cu,Fe and Mn etc.four trace elements in it were determined by atomic absorption spectrometry.[Results] The contents of GSH and SOD in middle dose group were obvious higher than that in the control group(P<0.05).The contents of Cu,Fe and Mn in middle and high dose groups were obvious higher than that in the control group(P<0.05).[Conclusion] FRUCTUS SCHISANDRAE CHINENSIS could enhance the hepatic antioxidant ability of mice significantly through maintaining the balance of trace elements in liver.
[Objective] To study the effects of FRUCTUS SCHISANDRAE CHINENSIS on the hepatic antioxidant system and trace elements in mice. [Methods] 40 male ICR mice were randomly divided into control group, low dose group, middle dose group and high dose group. Intragastric administration for 4 weeks, and then the content of reduced glutathione (GSH), malondialdehyde (MDA) and superoxide dismutase (SOD) in the hepatic tissue were digested by HNO3-HClO4 mixed acid, and the contents of Zn, Cu, Fe and Mn etc. trace trace elements in it were determined by atomic absorption spectrometry. [Results] The contents of GSH and SOD in middle dose group were obvious higher than that in the control group (P <0.05). Contents Cu, Fe and Mn in middle and high dose groups were significantly higher than that in the control group (P <0.05). [Conclusion] FRUCTUS SCHISANDRAE CHINENSIS could enhance the hepatic antioxidant ability of mice significantly through maintaining the balance of trace elements in liver.