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用~(125)I—UdR释放法研究绿舒筋对带瘤小鼠腹腔巨噬细胞(Mφ)细胞毒功能的调节作用发现,一定剂量的绿舒筋注射液能显著增强数种带瘤鼠腹腔Mφ对P815(甲基胆蒽诱发的小鼠肥大细胞瘤细胞)的溶解作用。用药带瘤鼠组与未用药带瘤鼠组比较,前者Mφ对肿瘤细胞的溶解率显著高于后者(P<0.01).体外实验结果表明,其Mφ杀瘤细胞活性的增强,可能与药物促进Mφ接受γ-干扰素(IFN-γ)等细胞因子的活化作用有关。
A ~(125)I-UdR release assay was used to investigate the effect of Lushujin on the cytotoxicity of tumor-bearing mice peritoneal macrophages (Mφ). It was found that a certain dose of Lushujin injection could significantly enhance several tumor-bearing mice. Dissolution of P815 (methylcholanthrene induced murine mast cell tumor cells) by intraperitoneal Mφ. The dissolution rate of tumor cells in the former group was significantly higher than that in the latter group (P<0.01). The in vitro results showed that the activity of Mφ tumorigenic cells could be enhanced with the drug. The promotion of Mφ is related to the activation of cytokines such as IFN-γ.