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目的 探讨乙型肝炎患者的乙型肝炎病毒 (HBV)血清学标志 (HBVM )与HBVDNA检测结果的相关性与临床意义。方法 对 414例乙型肝炎的HBVM和HBVDNA检测结果进行比较。HBVM用ELISA定量分析法检测 ,HBVDNA用斑点杂交法检测。结果 急性、慢性乙型肝炎患者中HBVDNA的阳性率与乙型肝炎肝硬化患者的HBVDNA阳性率比较 ,差异有显著性 ;HBsAg、抗 HBe、抗 HBc阳性和HBsAg、HBeAg、抗 HBc阳性组的HBVDNA阳性率比较 ,差异无显著性 ;HBsAg和 或HBeAg的滴度与HBVDNA阳性率呈正相关关系。 结论 HBVDNA是评价HBV活动最理想的标志 ;抗 HBe的出现不能作为HBV复制停止的指标 ;HBsAg的滴度和HBeAg的滴度变化可作为临床评价病毒复制程度和抗病毒疗效的参考指标
Objective To investigate the correlation and clinical significance of hepatitis B virus (HBV) serological markers (HBVM) and HBVDNA in hepatitis B patients. Methods 414 cases of hepatitis B HBVM and HBVDNA test results were compared. HBVM was detected by ELISA, HBVDNA was detected by dot blot hybridization. Results The positive rates of HBVDNA in acute and chronic hepatitis B patients were significantly different from those in patients with hepatitis B cirrhosis. The positive rates of HBVDNA in HBsAg, anti-HBe, anti-HBc and HBsAg, HBeAg and anti-HBc The positive rate of HBsAg and HBeAg was positively correlated with the positive rate of HBVDNA. Conclusions HBVDNA is the best indicator to evaluate the activity of HBV. The appearance of anti-HBe can not be used as an indicator of stopping HBV replication. The titer of HBsAg and the change of HBeAg titer can be used as a reference index to evaluate the degree of virus replication and anti-virus efficacy