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肝纤维化的形成过程是致病因素(如病毒、寄生虫感染、毒物等)导致肝细胞变性、坏死及炎症反应,激活枯否氏细胞释放一些促纤维化因子(如TGF-β_1等),随同血小板、肝窦内皮细胞和肝细胞等分泌的多种细胞因子,与某些化学介质共同作用于肝星状细胞(Hepatic Stellate Cell.HSC)致使HSC激活,转化为肌成纤维细胞,通过旁分泌或自分泌作用,使HSC增殖、合成大量的细胞外基质(extracellular matrix.ECM)。另
The formation of liver fibrosis is caused by pathogenic factors (such as viruses, parasitic infections, poisons, etc.) leading to hepatocellular degeneration, necrosis and inflammatory response, activating Kupffer cells to release some pro-fibrotic factors (such as TGF- Along with platelets, sinusoidal endothelial cells and liver cells and other secreted a variety of cytokines, and some chemical mediators act on hepatic stellate cells (HSC) HSC activation, into myofibroblasts, by next Secretion or autocrine function, HSC proliferation, the synthesis of a large number of extracellular matrix (extracellular matrix. ECM). another