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目的:评价具有温阳复心、活血利水作用的复心合剂对慢性心力衰竭(CHF)心阳虚衰证患者淋巴细胞β1-AR mRNA表达的影响及临床治疗效果。方法:60例慢性心力衰竭心阳虚衰证患者,随机分为对照组(缬沙坦组)30例、治疗组(复心合剂组)30例,经6周治疗后,观察患者外周血淋巴细胞β1-AR mRNA表达、6min步行试验(6MWT)、脑钠肽(BNP)及生活质量评分的变化,观察复心合剂改善心衰患者的临床疗效。结果两组心衰患者外周血淋巴细胞β1-AR mRNA表达量较治疗前明显提高(P<0.01);患者6WMT距离较治疗前明显增加(P<0.01),且6WMT心功能分级较治疗前明显改善(P<0.01);患者血浆BNP水平较治疗前明显降低(P<0.01);明尼苏达心力衰竭生活质量评分较治疗前明显降低(P<0.01),患者生活质量明显改善。结论复心合剂能提高心衰患者外周血淋巴细胞β1-AR mRNA的表达,并有效提高CHF患者运动耐量,降低血浆BNP水平,改善生活质量。
OBJECTIVE: To evaluate the effect of Fuxin Mixture on the lymphocyte β1-AR mRNA expression in patients with heart failure and heart failure (CHF) with chronic heart failure (CHF) and the clinical therapeutic effect. Methods: Sixty patients with heart failure syndrome of chronic heart failure were randomly divided into control group (valsartan group) 30 cases and treatment group (compound group) 30 cases. After 6 weeks ’treatment, the patients’ peripheral blood lymph The expression ofβ1-AR mRNA, 6MWT (6MWT), BNP and QOL were observed to observe the clinical effect of Fuxin Mixture in improving heart failure patients. Results The expression of β1-AR mRNA in peripheral blood lymphocytes in two groups of patients with heart failure was significantly higher than that before treatment (P <0.01). The distance of 6WMT in patients with heart failure was significantly higher than that before treatment (P <0.01) (P <0.01). Plasma BNP levels in patients were significantly lower than those before treatment (P <0.01). The quality of life in patients with heart failure in Minnesota was significantly lower than that before treatment (P <0.01), and the quality of life was significantly improved. Conclusion Fuxin Compound can improve the expression of β1-AR mRNA in peripheral blood lymphocytes of patients with heart failure, and improve the exercise tolerance, decrease the plasma BNP level and improve the quality of life in CHF patients.