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An efficient 1-methylimidazole-catalyzed synthesis of dialkyl 2-[(4-methylphenyl)sulfonyl]-1H-pyrrole-3,4-dicarboxylates is described.The reactive 1:1 zwitterionic intermediate formed by the addition of 1-methylimidazole to dialkyl acetylenedicarboxylates is trapped by tosylmethyl isocyanide(TOSMIC) to afford the title compounds in excellent yields.
An efficient 1-methylimidazole-catalyzed synthesis of dialkyl 2 - [(4-methylphenyl) sulfonyl] -1H-pyrrole-3,4-dicarboxylates is described. Reactive 1: 1 zwitterionic intermediate formed by the addition of 1-methylimidazole to dialkyl acetylenedicarboxylates is trapped by tosylmethyl isocyanide (TOSMIC) to afford the title compounds in excellent yields.