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1例29岁男性患者,因肺结核服用复方利福平胶囊(每粒含利福平600mg,异烟肼600mg),1粒/次,隔日1次。治疗3个月后症状好转自行停药。1年后患者再次出现咳嗽、盗汗等症状,遂按原治疗剂量自行服用复方利福平胶囊。服药8d后,出现恶心、呕吐,腰痛,颜面及双下肢水肿,少尿、茶色尿。实验室检查:BUN21.2mmol/L,SCr877.8μmol/L,尿蛋白(+),尿潜血(+++);ECT检查示左肾和右肾GFR值分别为21.11ml/min和20.98ml/min。停用复方利福平胶囊,行血液透析,同时给予对症、支持治疗,25d后症状好转。
A 29-year-old man with tuberculosis taking rifampicin capsules (each containing rifampicin 600mg, isoniazid 600mg), 1 capsule / time, every other day. 3 months after treatment, the symptoms improved on their own withdrawal. 1 year after the patient again cough, night sweats and other symptoms, then according to the original dose of the compound taking rifampicin capsules. After medication 8d, nausea, vomiting, back pain, facial and lower extremity edema, oliguria, brown urine. Laboratory tests showed BUN21.2mmol / L, SCr877.8μmol / L, urinary protein (+) and urinary occult blood (+++). ECT showed that the GFR of the left and right kidneys were 21.11ml / min and 20.98ml / min. Disable the compound rifampin capsules, hemodialysis, symptomatic and supportive treatment, 25d after the symptoms improved.