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目的分析坦索罗辛和654-2在输尿管下段结石辅助排石中疗效。方法120例输尿管下段结石患者随机分3组,每组40例。结石直径0.4～0.8cm。组1为对照组,未给予输尿管平滑肌松弛剂;组2给予654-210mg,3次/d;组3给予坦索罗辛0.4mg,1次/d。每例患者治疗观察期不超过2周。结果2周内结石排出者组1为17例(42.5%),组2为29例(72.5%),组3为33例(82.5%),组2、3与组1比较排石率差异有统计学意义(P<0.05)。平均排石时间组1～3分别为10、7、4d,组1与组3比较差异有统计学意义(P<0.05),组2与组3比较差异无统计学意义(P>0.05)。2周内组1～3因再次发生肾绞痛而需镇痛治疗者分别为12例(30%)、5例(12.5%)和1例(2.5%),组间比较差异有统计学意义(P<0.05)。2周内3组均未出现明显不良反应,无因不能耐受而退出者。结论坦索罗辛和654-2在输尿管下段结石辅助排石方面安全、有效,能明显提高排石率。
Objective To analyze the curative effect of tamsulosin and 654-2 on calculi assisted by calculi in the lower ureter. Methods 120 patients with lower ureteral stones were randomly divided into 3 groups, 40 cases in each group. Stone diameter 0.4 ~ 0.8cm. Group 1 was the control group, and no ureteral smooth muscle relaxant was given; group 2 was given 654-210mg, 3 times / d; group 3 was given tamsulosin 0.4mg, 1 time / d. Each patient treatment observation period of no more than 2 weeks. Results In 2 weeks, there were 17 cases (42.5%) in group 1, 29 cases (72.5%) in group 2, 33 cases (82.5%) in group 3, and Statistical significance (P <0.05). The mean time to stone row was 1 to 3 for 10, 7 and 4 days respectively. There was significant difference between group 1 and group 3 (P <0.05). There was no significant difference between group 2 and group 3 (P> 0.05). There were 12 cases (30%), 5 cases (12.5%) and 1 case (2.5%) in group 1 ~ 3 for analgesia due to recurrence of renal colic. The difference between the two groups was statistically significant (P <0.05). No significant adverse reactions occurred in any of the 3 groups within 2 weeks, and no patients were withdrawn due to unacceptable tolerance. Conclusion Tamsulosin and 654-2 are safe and effective in removing calculi in the lower ureteral calculi and can significantly improve the rate of discharged rock.