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目的探讨煤工尘肺发生的自由基机制.方法系统测定了104例不同期别煤工尘肺患者及40例无粉尘接触史的健康对照者机体的脂质过氧化及抗氧化状态.结果各期别煤工尘肺机体的过氧化脂质(LPO)水平、超氧化物歧化酶(SOD)活力、还原型谷胱甘肽(GSH)及铜含量均显著高于对照组(P＜0?01),而谷胱甘肽过氧化物酶(GSH?PX)及过氧化氢酶(CAT)活力则较对照组显著降低(P＜0?01).结论煤工尘肺的发生与机体自由基代谢的紊乱及氧化/抗氧化状态的失衡有关.“,”In order to explore the free radical mechanism in the pathogenesis of coal workers? pneumoconiosis(CWP),the CWP lipid peroxidation and antioxidation status in 104 patients with different stage(Ⅰ,Ⅱ,Ⅲ)and 40 healthy workers unexposed to coal dust were systematically determined.The results showed that the content of lipid peroxides(LPO),the activity of superoxide dismutase(SOD),the level of glutathione(GSH)and serum copper(Cu)level in CWP patients were s...