目的：应用原子吸收光谱法，以硫酸锌作对照，对枸橼酸锌的急性毒性和在家兔体内的药物动力学进行实验性研究。方法：对家兔做毒性实验和药物动力学研究。结果：此两种药物口服均为开放式一室模型，枸橼酸锌口服毒性低，相对生物利用度为２３６％。结论：枸橼酸锌的毒性较低，对胃肠道的刺激性小，其吸收性好，生物利用度较高 OBJECTIVE: To study the acute toxicity of zinc citrate and its pharmacokinetics in rabbits by using atomic absorption spectrometry and zinc sulfate as control. Methods: Toxicity tests and pharmacokinetic studies were performed on rabbits. RESULTS: Oral administration of both drugs was an open-chamber model. Oral toxicity of zinc citrate was low and the relative bioavailability was 236%. CONCLUSIONS: Zinc citrate is less toxic, less irritating to the gastrointestinal tract, has good absorption and high bioavailability