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患者男,39岁,教师。因双耳廓、面部、四肢、唇粘膜部反复出疼痛性水疱、伴口腔溃疡7年,于1992年9月以待诊收入住院。于7年前春季无明显诱因先双耳廓、舌尖、舌缘部疼痛,随即出现米粒至黄豆大小的水疱,疱壁紧张,疱液清亮、水疱散在或成族分布,疱周有水肿性红晕,局部水疱处自觉刺痛。在出水疱前有疲乏、精神不振前驱症状,临近出水疱时局部皮肤疼痛剧烈,并伴有烦躁、失眠、口干、四肢潮热,甚至因疼痛卧床不起。每次发病只有皮质类固醇激素才能缓解,其他镇痛剂无效。不论治疗与否,水疱约经3～5周“痊愈”,但数周或数月后又复发,且愈发愈多,部位基本固定,既往史及家族史无特殊。
Male patient, 39 years old, teacher. Due to the double pinna, face, limbs, lips and mucous membrane pain repeatedly blisters, with oral ulcers for 7 years, in September 1992 to be admitted to hospital. 7 years ago, there was no obvious incentive in the spring before the double ear contour, tongue, tongue margin pain, then the size of rice to soybeans blisters, blister wall tension, blister fluid clear, blisters scattered or ethnic distribution, vesicular edema blisters Local blisters conscious tingling. In the blisters before the fatigue, lack of energy prodromal symptoms, near the blisters when the local skin pain and severe, accompanied by irritability, insomnia, dry mouth, limbs hot flashes, and even pain in bed. Only corticosteroids can alleviate the incidence of each other, other analgesics ineffective. Regardless of treatment or not, the blister is “cured” after about 3 to 5 weeks, but relapsing after a few weeks or months, and more and more, the site is basically fixed, past history and family history is no special.