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目的:研究楤木皂苷对大鼠肝纤维化的影响及其可能的机制。方法:采用皮下注射四氯化碳诱导大鼠肝纤维化模型,楤木皂苷给药8周,MASSON染色观察胶原纤维增生情况,检测各组大鼠肝脾指数、血清肝功能、LN、COI-Ⅲ、COI-Ⅳ的变化。结果:楤木皂苷30 mg/kg、60 mg/kg可减少肝细胞变性、坏死和纤维增生程度,改善肝功能,降低血清中LN、COI-Ⅲ、COI-Ⅳ的含量。结论:楤木皂苷对大鼠肝纤维化有防治作用,其机制可能与保护肝功能、降低血清中LN、COI-Ⅲ、COI-Ⅳ的含量有关。
Objective: To study the effect of albinoside on liver fibrosis in rats and its possible mechanism. Methods: The model of hepatic fibrosis was induced by subcutaneous injection of carbon tetrachloride. Alginate was administered for 8 weeks. MASSON staining was used to observe the proliferation of collagen fibers. The liver and spleen index, serum liver function, LN, COI- Ⅲ, COI-Ⅳ changes. Results: Almus saponins 30 mg / kg, 60 mg / kg can reduce the degree of liver cell degeneration, necrosis and fibrogenesis, improve liver function and reduce the content of LN, COI-Ⅲ and COI-Ⅳ in serum. CONCLUSION: Alnus saponins can prevent and cure hepatic fibrosis in rats. The mechanism may be related to the protection of hepatic function and the reduction of serum levels of LN, COI-Ⅲ and COI-Ⅳ in rats.