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唇腭裂是人类最常见的先天性畸形之一,其群体发病率为1‰~2‰,不同国家发病率相差很大,在我国达1.82‰[1]。唇腭裂病因至今尚不明了,传统上认为由多基因遗传因素造成,与环境诱变因子有重大关系。胚胎早期的外环境,包括病毒感染、化学药物、毒物、放射线、环境污染、缺氧、妊娠
Cleft lip and palate is one of the most common congenital malformations in humans. Its population incidence is 1 ‰ ~ 2 ‰, and the incidence in different countries varies greatly, reaching 1.82 ‰ in China [1]. The etiology of cleft lip and palate remains unclear, traditionally thought to be caused by multiple genetic factors, and environmental mutagens have a significant relationship. Early embryonic external environment, including viral infections, chemicals, poisons, radiation, environmental pollution, hypoxia, pregnancy