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目的探讨腋窝淋巴结阴性浸润性乳腺癌患者的分子分型及其预后情况。方法回顾性分析2006年12月至2009年6月间180例腋窝淋巴结阴性浸润性乳腺癌的临床病理资料,并按照雌激素受体(ER)、孕激素受体(PR)及人类表皮生长因子受体-2(HER-2)的检测结果将其分为管腔上皮(Luminal)型、基底样(Basal-like)型及HER-2过表达(over-expression)型,观察不同分型乳腺癌在不同年龄、肿瘤大小及分期中的表达及预后情况。结果 180例腋窝淋巴结阴性浸润性乳腺癌患者中,Luminal型、Basal-like型、HER-2过表达型分别占54.4%(98/180)、27.8%(50/180)和17.8%(32/180)。Luminal型、Basal-like型、HER-2过表达型在不同年龄、肿瘤大小及临床分期中的表达差异无统计学意义(P>0.05)。Basal-like型患者术后36和60个月的转移率分别为14.0%和36.0%,高于Luminal型的3.1%、20.4%及HER-2过表达型的6.3%、21.9%,差异有统计学意义(P<0.05)。Basal-like型患者术后60个月的死亡率为24.0%,高于Luminal型(10.2%)及HER-2过表达型(15.6%),HER-2过表达型患者术后60个月的死亡率高于Luminal型,差异有统计学意义(P<0.05)。结论腋窝淋巴结阴性浸润性乳腺癌的分子分型以Lumina1型最为常见,Basal-like型与HER-2过表达型构成比较低,其中Basal-like型患者预后较差,其次为HER-2过表达型患者。
Objective To investigate the molecular typing and prognosis of patients with axillary lymph node-negative invasive breast cancer. Methods The clinical data of 180 cases of axillary lymph node-negative invasive breast cancer from December 2006 to June 2009 were retrospectively analyzed. According to the clinical data of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor The results of HER-2 were divided into Luminal type, Basal-like type and HER-2 over-expression type. Breast of different types was observed Cancer in different age, tumor size and stage of the expression and prognosis. Results In 180 cases of axillary lymph node-negative invasive breast cancer, Luminal, Basal-like and HER-2 overexpression accounted for 54.4% (98/180), 27.8% (50/180) and 17.8% 180). The expression of Luminal type, Basal-like type and HER-2 overexpression in different age, tumor size and clinical stage had no statistical significance (P> 0.05). Basal-like patients 36 and 60 months after the transfer rate was 14.0% and 36.0%, higher than Luminal 3.1%, 20.4% and HER-2 over-expression of 6.3%, 21.9%, the difference was statistically significant Significance (P <0.05). The death rate at 60 months after operation in Basal-like patients was 24.0%, higher than that in patients with Luminal type (10.2%) and HER-2 overexpression (15.6%), and those with HER-2 overexpression The mortality rate was higher than that of Luminal type, the difference was statistically significant (P <0.05). Conclusion The molecular classification of axillary lymph node-negative invasive breast cancer is most common in Lumina1 type. Basal-like type and HER-2 over-expression type are relatively low. Basal-like type patients have poor prognosis, followed by HER-2 overexpression Type of patients.