论文部分内容阅读
瞬时受体电位香草酸亚型1(transient receptor potential vaniuoed 1,TRPV1)是非选择性阳离子通道,可被多种配体及刺激激活。TRPV1在组织缺血再灌注损伤(ischemia-reprefusion injury,IRI)中的作用已在多个器管中被证实。现就对TRPV1在IRI中的病理生理机制及TRPV1激动剂在肺IRI中的保护作用及应用价值进行综述。
Transient receptor potential vaniuoed 1 (TRPV1) is a non-selective cation channel that can be activated by various ligands and stimuli. The role of TRPV1 in ischemia-reprefusion injury (IRI) has been demonstrated in multiple vessels. The pathophysiological mechanism of TRPV1 in IRI and the protective effect of TRPV1 agonist in lung IRI are reviewed.