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目的 研究氟桂利嗪作为添加剂 ,采用剂量递增法治疗难治性癫痫部分性发作的疗效和安全性。方法 对 1997年 1月至 2 0 0 0年 1月收治的 43例难治性部分性发作患者 (男 2 5例 ,女 18例 ,年龄 8～ 5 6岁 ) ,进行氟桂利嗪添加治疗的开放性自身对照研究 ,原服用的抗癫痫药种类和剂量不变。氟桂利嗪剂量递增给药方法为 :8～ 12岁儿童 ,第 1周口服 5mg/d ,以后每周增加 5mg/d ;成人第1周口服 10mg/d ,以后每周增加 10mg/d ;至第 4周时 ,儿童以 2 0mg/d、成人以 40mg/d维持量给药 ,分 2次口服 ,连续观察半年。结果 2例失访 ,3例因不能耐受的副反应 ,在剂量递增期间退出观察。38例完成氟桂利嗪剂量递增添加治疗。总有效率为 6 3% ,其中单纯部分性发作 (SPS)有效率为 75 % ,复杂部分性发作 (CPS)为 6 2 % ,继发性全身性发作 (SGS)为 5 6 %。同添加治疗前比较 ,总的发作频率减少 6 9% ,其中SPS为 73% ,CPS为 6 6 % ,SGS为 5 7%。脑电图呈中度或重度异常的患者比例 ,由 76 %下降到 47%。治疗前后的心电图及肝、肾、血、尿等化验检查均无明显变化。 16例患者出现轻度副反应 ,但未影响治疗。结论 氟桂利嗪作为添加剂 ,用剂量递增法治疗难治性癫痫部分性发作 ,疗效确切 ,安全性较高
Objective To study the efficacy and safety of flunarizine as an additive in the treatment of partial seizures of refractory epilepsy with dose escalation. Methods Forty-three patients with refractory partial seizures (25 males and 18 females, aged 8-56 years) admitted to our hospital from January 1997 to January 2000 were treated with flunarizine Open self-control study, the original type of anti-epileptic drugs and dosage unchanged. Flunarizine dose escalation method: 8 to 12-year-old children, the first week of oral 5mg / d, after a weekly increase of 5mg / d; adult 1 week oral 10mg / d, after a weekly increase of 10mg / d; By the 4th week, the children were given 20 mg / d and 40 mg / d as the maintenance dose. They were orally administered orally twice a day for six months. Results Two patients were lost to follow-up and three patients were excluded from observation during dose escalation due to unacceptable side effects. 38 patients completed flunarizine dosage increase treatment. The total effective rate was 63%. The effective rate of simple partial seizure (SPS) was 75%, complex partial seizure (CPS) was 62%, and secondary generalized seizure (SGS) was 56%. Compared with pre-treatment, the total seizure frequency decreased by 69%, of which SPS was 73%, CPS was 6 6% and SGS was 57%. The proportion of patients with moderate or severe EEG was decreased from 76% to 47%. ECG before and after treatment and liver, kidney, blood, urine and other laboratory tests showed no significant change. 16 patients with mild side effects, but did not affect the treatment. Conclusion Flunarizine as an additive, with dose escalation method for the treatment of partial seizures refractory epilepsy, the exact effect, high safety