青霉素是抗菌素中毒性最小但过敏反应发生率最高的一种,其中过敏休克又是最严重的反应,直接影响病人的生命安全。青霉素过敏休克的机制是个长期未解决的问题,近年来国内外研究认为青霉素杂质是引起过敏反应的过敏原。有的认为青霉噻唑基团是青霉素过敏反应抗原的主要决定簇,有的认为青霉噻唑基团以外的某些杂质(次要决定簇)同青霉素过敏休克的发生有直接关系,未取得一致意见。为了研究青霉噻唑基团和发生过敏休克之间的关系,我们用青霉噻唑蛋白致敏豚鼠,以青霉素 G 和青霉噻唑蛋白等作抗原攻击,通过观察动物过敏休克的发生与被动致敏大鼠腹腔 Penicillin is the least toxic but the highest incidence of allergic reactions, allergic shock which is the most serious reaction, a direct impact on the patient’s life safety. The mechanism of penicillin anaphylactic shock is a long-standing problem that has not been solved in recent years, domestic and foreign studies believe that penicillin impurity allergens cause allergic reactions. Some think that the penicillin thiazole group is the main determinant of penicillin anaphylaxis antigen, and some think outside the penicillium thiazole group of impurities (secondary determinants) with penicillin allergy shock has a direct relationship, not consistent opinion. In order to study the relationship between penicillium thiazole group and the occurrence of anaphylactic shock, we used penicillin zygote sensitized guinea pigs to penicillin G and penicillin thiazole protein for antigen attack, by observing the occurrence of animal anaphylactic shock and passive sensitization Rat abdominal cavity