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目的 观察抑癌基因 P2 1 和表皮生长因子受体 EGFR在肺癌组织中的表达。方法 用免疫组化 SP法对 31例肺癌组织中的 P2 1 和 EGFR表达进行检测。结果 肺癌组织中 P2 1 和 EGFR表达较正常肺组织高 ,其中 P2 1 和 EGFR在肺癌组织中的阳性表达率分别为 41.9%和 70 .97% ,P2 1 、EGFR表达与肺癌分期及淋巴结转移有关。结论 P2 1 与 EGFR在肺癌的发生、发展中起一定作用 ,可作为肺癌预后判断的参考指标。
Objective To observe the expression of tumor suppressor gene P2 1 and epidermal growth factor receptor EGFR in lung cancer. Methods The expressions of P2 1 and EGFR in 31 cases of lung cancer were detected by immunohistochemical SP method. Results The expressions of P2 1 and EGFR in lung cancer tissues were higher than those in normal lung tissues. The positive expression rates of P2 1 and EGFR in lung cancer tissues were 41.9% and 70.97% respectively. The expressions of P2 1 and EGFR were correlated with the stage of lung cancer and lymph node metastasis . Conclusion P2 1 and EGFR play a role in the occurrence and development of lung cancer and can be used as a reference index for prognosis of lung cancer.