脑钠肽(BNP)1988年由Sudoh等[1]首先从猪脑中提炼出来的,后来又在人的心脏中分离纯化出BNP,且发现其分泌量高于脑。BNP属于钠肽家族中的B型,也称B型尿钠肽。生理情况下,BNP主要来源于心房,心房肌细胞的分泌颗粒中含有少量的BNP,心房BNP含量是心室的50～100倍;心功能不全时,BNP主要的合成位点在心室,因此又称为“心室BNP”。 Brain natriuretic peptide (BNP) was first extracted from porcine brain by Sudoh et al [1] in 1988 and was later isolated and purified from human heart. BNP was found to be secreted more than the brain. BNP belongs to type B of the natriuretic peptide family, also known as type B natriuretic peptide. Physiological circumstances, BNP mainly from the atrium, atrial myocyte secretion of granules contains a small amount of BNP, atrial BNP content is 50 to 100 times the ventricular; cardiac insufficiency, BNP main synthesis site in the ventricular, also known as For “Ventricular BNP”.