一旦拟診白喉应立刻給予病人白喉抗毒素,已为人所共知。但对給葯途径却存有不同意見。作者經过对病人的观察及大量动物試驗,認为靜脉注射白喉抗毒素有其重要意义。 (一)靜脉注射白喉抗血清后,病人血浆中之抗毒素效价,几乎可立刻达到最高值。换言之,全部白喉抗毒素可以很快由血液輸送至各有关器官。而肌肉注射則吸收很慢,平均需4天始吸收完全。 (二)做为一种非特異性蛋白,靜脉注射的抗毒素并不比肌肉注射时在体內破坏或排泄的更快。 (三)靜脉注射抗毒素后,在30分鐘短时間內,卽可通过唾液腺排入唾液。从此时起唾液卽为无毒的。以后流經发炎受損之扁桃体及咽壁时,毒素不再由唾液所吸收。而在肌肉注射抗血清則常需若干小 Once diphtheria to be diagnosed should be given to patients diphtheria anti-toxin, has been well-known. But there are different views on the route of administration. After the patient’s observation and a large number of animal experiments that the diphtheria anti-toxin has its significance. (A) After the diphtheria antiserum is administered intravenously, the antitoxin titer in the patient’s plasma reaches the highest value almost immediately. In other words, all diphtheria antitoxin can be rapidly delivered from the blood to all relevant organs. The intramuscular injection is very slow, an average of 4 days before absorption completely. (B) As a nonspecific protein, intravenous antitoxin is no more rapidly destroyed or excreted in vivo than intramuscular injection. (C) intravenous antitoxin, in a short period of 30 minutes, 卽 saliva can be discharged through the salivary glands. Saliva is non-toxic from this point on. After the flow of inflammation through the tonsils and pharynx wall, toxins are no longer absorbed by the saliva. In the muscle injection of antisera often require some small