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目的 探讨局部振动对肿瘤坏死因子 (tumornecrosisfactor,TNF)的影响及其意义。方法 将家兔随机分为A组 (接振强度 3.0 3m s2 ,每天接振 0 .5h)、B组 (接振强度 6 .13m s2 ,每天接振 1h)、C组 (接振强度 12 .2 5m s2 ,每天接振 1h)和 1个对照组 (D组 )。各接振组均进行 30d接振试验。分别于试验前、试验第 10、2 0、30天对各组家兔进行血清TNF浓度的测定及分析。结果 在试验前及试验第 10、2 0、30天 ,A组TNF浓度分别为 (3.10± 0 .39)、(3.2 7± 0 .5 8)、(3.79± 0 .5 1)、(4 .16±0 .31) μg L ,B组分别为 (3.16± 0 .4 9)、(3.5 7± 0 .4 3)、(4 .14± 0 .6 9)、(4 .4 8± 0 .4 7) μg L ,C组分别为(3.2 1± 0 .37)、(3.91± 0 .5 0 )、(4 .4 6± 0 .5 9)、(4 .88± 0 .5 4 ) μg L ,D组分别为 (3.2 4± 0 .5 8)、(3.36±0 .6 9)、(3.33± 0 .6 1)、(3.19± 0 .39) μg L。与试验前和实验相同时间对照组比较 ,接振组家兔血清TNF浓度呈增高趋势 ,且差异均有显著性 (P <0 .0 5 ,P <0 .0 1)。结论 局部振动所导致血清中TNF浓度的变化可能与振动病的发病机制有一定关系。
Objective To investigate the effect of local vibration on tumor necrosis factor (TNF) and its significance. Methods Rabbits were randomly divided into group A (group receiving vibration intensity 3.0 3m s2, receiving vibration 0.5h per day), group B (receiving vibration intensity 6.13m s2, vibration receiving 1h per day), group C (vibration intensity 12) 2 5m s2, each day vibration 1h) and a control group (D group). Each vibration group were 30d vibration test. The levels of TNF in serum of each group were measured and analyzed on the 10th, 20th, 30th days of the experiment before the experiment. Results Before the experiment and on the 10th, 20th and 30th day of the experiment, the TNF concentrations in group A were (3.10 ± 0.39), (3.2 7 ± 0.58), (3.79 ± 0.51) and (4 .16 ± 0.31) μg L, respectively, while those in group B were (3.16 ± 0.49), (3.57 ± 0.43), (4.14 ± 0.96), (4.48 ± (P <0.05), while the difference between the two groups was statistically significant (P <0.01) 4) μg L, respectively, and those in group D were (3.2 4 ± 0.58), (3.36 ± 0.96), (3.33 ± 0.61) and (3.19 ± 0.39) μg L, respectively. Compared with the control group before the experiment and at the same time of the experiment, the serum TNF concentration of the rabbits in the vibration-receiving group showed an increasing tendency, and the difference was significant (P <0.05, P <0.01). Conclusion The changes of serum TNF concentration caused by local vibration may be related to the pathogenesis of vibrational disease.