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结构性质独特的树形大分子有望在基因药物传递等生物医药领域有广阔应用。理解其在水溶液中的结构性质,对于其应用开发具有重要指导意义。小角中子散射方法非常适合直接探测溶液中大分子的结构。树形大分子虽具有极好的单分散性质,但体系中仍可能存在二聚体等结构缺陷。利用小角散射方法测量第五代PAMAM树形大分子溶液散射,通过小角中子散射间接傅里叶变换分析,推测出溶液中粒子的最
Structurally unique tree-shaped macromolecules are expected to have broad applications in the field of biomedicine such as gene delivery. Understanding its structural properties in aqueous solution has important guiding significance for its application and development. The small angle neutron scattering method is very suitable for the direct detection of the structure of the macromolecules in solution. Although the dendrimers have excellent monodisperse properties, structural defects such as dimers may still exist in the system. The scattering of fifth-generation PAMAM dendrimer was measured by the method of small-angle scattering. By indirect Fourier transform analysis of small-angle neutron scattering, it was deduced that the particle size in solution