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目的探讨胸腔积液肿瘤标志物CEA、NSE和CYFR21-1联检对肺癌的诊断价值。方法检测不同病理类型肺癌患者血清和胸腔积液CEA、NSE和CYFR21-1水平。结果 (1)肺癌组织CEA、NSE和CYFR21-1胸腔积液水平明显高于良性胸腔积液组(P<0.01);(2)肺癌组织CEA、NSE和CYFR21-1胸腔积液水平明显高于血清水平;(3)肺腺癌的CEA、小细胞肺癌的NSE、肺鳞癌的CYFR21-1血清及胸腔积液水平高于其他病理类型肺癌(P<0.01);CEA对肺腺癌,NSE对小细胞肺癌、CYFR21-1对肺鳞癌的诊断灵敏度明显高于其他单项肿瘤标志物(P<0.01);(4)胸腔积液CEA、NSE和CYFR21-1单项检测对肺癌诊断灵敏度明显高于血清(P<0.05);CEA+NSE+CYFR21-1诊断灵敏度明显高于单项肿瘤标志物(P<0.05)。结论胸腔积液CEA、NSE和CYFR21-1联合检测有助于肺癌临床诊断。
Objective To investigate the diagnostic value of pleural effusion tumor markers CEA, NSE and CYFR21-1 in lung cancer. Methods The levels of CEA, NSE and CYFR21-1 in serum and pleural effusion of patients with different pathological types of lung cancer were detected. Results (1) The levels of CEA, NSE and CYFR21-1 in lung cancer were significantly higher than those in benign pleural effusion (P <0.01). (2) The levels of CEA, NSE and CYFR21-1 in lung cancer were significantly higher than those in benign pleural effusion (3) The levels of CEA in lung adenocarcinoma, NSE in small cell lung cancer, CYFR21-1 serum and pleural effusion in lung squamous cell carcinoma were higher than those in other pathological types (P <0.01) For small cell lung cancer, the diagnostic sensitivity of CYFR21-1 to squamous cell carcinoma of the lung was significantly higher than that of other single tumor markers (P <0.01). (4) The sensitivity of single detection of CEA, NSE and CYFR21-1 in pleural effusion to lung cancer was significantly higher (P <0.05). The diagnostic sensitivity of CEA + NSE + CYFR21-1 was significantly higher than that of single tumor markers (P <0.05). Conclusion Combined detection of CEA, NSE and CYFR21-1 in pleural effusion is helpful for the clinical diagnosis of lung cancer.