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目的 研究氟脱氯葡萄糖F18 正电子发射计算机电子扫描 (1 8FDG PET)在鉴别肺部肿块性质和肺癌术前纵隔淋巴结转移分期中的应用价值。 方法 对 34例肺部肿块患者进行1 8FDG PET和CT检查 ,PET资料分别采用目测法和计算标准化摄取值 (SUV)的半定量法进行分析 ,并同病理结果对照。 结果 目测法1 8FDG PET诊断肺部肿块性质的敏感度、准确度分别是 93%、85 % ;CT分别为 6 3%、5 3% ,2种方法差异有显著性意义 (P <0 0 5 ) ;半定量法准确度为 74% ,与CT相比 ,差异也有显著性意义 (P <0 0 5 )。肺部恶性肿块的SUV是 4 4± 1 9,良性为 2 2± 1 7,2者差异有显著性意义 (P <0 0 5 )。1 8FDG PET和CT 2种检查方法术前对纵隔淋巴结转移的分期与病理结果符合率分别为10 0 %和 78% ,2者差异有显著性意义 (P <0 0 5 )。 结论 同CT相比 ,1 8FDG PET能更准确地鉴别肺部肿块性质及确定纵隔淋巴结转移分期 ,是一种较好的无创性肺癌诊断技术。
Objective To study the application value of fluorodeoxyglucose F18 positron emission computerized scanning (18FDG PET) in distinguishing the nature of lung mass and the staging of lung cancer before operation. Methods 18 FDG PET and CT were performed on 34 patients with pulmonary masses. The PET data were analyzed by visual inspection and semi-quantitative calculation of standardized uptake (SUV), and compared with pathological results. Results The sensitivity and accuracy of the 8FDG PET in the diagnosis of pulmonary masses were 93% and 85%, respectively, and the CT values were 6 3% and 5 3% respectively. There was a significant difference between the two methods (P <0 0 5 The accuracy of the semi-quantitative method was 74%. Compared with CT, the difference was also significant (P <0 05). The SUV of malignant lung mass was 4 4 ± 1 9 and benign was 2 2 ± 1 7, 2 with significant difference (P <0 05). The 8FDG PET and CT examinations showed that the coincidence rates of staging and pathological findings of mediastinal lymph node metastasis were 100% and 78% respectively. There was a significant difference between the two (P < 0.05). Conclusion Compared with CT, 18FDG PET can more accurately identify the characteristics of lung mass and determine the staging of mediastinal lymph nodes. It is a good non-invasive diagnosis technique for lung cancer.