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甲_2—巨球蛋白(α_2—Macroglobulin,α_2M)广泛存在于脊椎动物与哺乳类动物体内,是生物体较早出现的蛋白。正常时,由肝脏细胞、枯氏细胞、纤母细胞与单核吞噬细胞等合成。炎症时,可有淋巴细胞类组织参与应急α_2M的合成。α_2M为大分子球蛋白,分子量为725000,已公认为广谱蛋白水解酶抑制剂。它能结合几乎所有类型的肽链内切酶,可与胰蛋白酶、激肽释放酶、组织蛋白酶、胶原酶等结合,并抑制其功能(1),有清除机体内源性及外源性过多蛋白水解酶的生理作
Alpha-2 macroglobulin (α_2-Macroglobulin, α_2M) is widely present in vertebrates and mammals, and is an early occurrence protein in organisms. Normally, it is synthesized by liver cells, Kupffer cells, fibroblasts and mononuclear phagocytes. In inflammation, lymphocyte tissues may participate in the synthesis of emergency α_2M. α_2M is a macroglobulin with a molecular weight of 725,000 and is widely known as a broad-spectrum proteolytic enzyme inhibitor. It binds almost all types of endopeptidases and binds to trypsin, kallikrein, cathepsins, collagenase, etc., and inhibits its function (1). It has the ability to eliminate endogenous and exogenous Physiological work of polyprotein hydrolase