成骨细胞是骨组织中的重要细胞 ,在骨的形成、发育、改建、修复过程中发挥重要作用 ,多种生长因子可影响成骨细胞的增殖、分化及其合成细胞外基质的作用。它们对成骨细胞的作用既有相似之处 ,也有不同点。寻找一种或联合应用几种不同的生长因子达到既能促进成骨细胞增殖又保持其成骨活性将是今后研究的热点。 Osteoblasts, as an important cell in bone, play an important role in the process of bone formation, development, remodeling and repair. Many growth factors can affect the proliferation and differentiation of osteoblasts and their roles in the synthesis of extracellular matrix. Their role in osteoblasts have similarities and differences. Looking for one or a combination of several different growth factors to achieve both promote osteoblast proliferation and maintain its osteogenic activity will be the focus of future research.