Protein prenylation and human diseases： a balance of protein farnesylation and geranylgeranylation

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：fuwutu

【摘要】

：

The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farne

【作者】

：

XU Na SHEN Ning WANG XiuXing J

【机构】

：

MinistryofEducationKeyLaboratoryofModelAnimalsforDiseaseStudy

【出处】

：

中国科学：生命科学英文版

【发表日期】

：

2015年4期

【关键词】

：

蛋白质修饰人类疾病烯化平衡类异戊二烯翻译后修饰半胱氨酸残基信号传导途径 protein prenylation GGPP FPP biolo

【基金项目】

：

This work was supported by the National Busic Research Program of Chi na （2012CB524900, 2009CB918703） and National Natural Science Foun dation of China （31271540, 30671086） awarded to Li ChaoJun.

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

The protein prenylation is one of the essential post-translational protein modifications, which extensively exists in the eukaryocyte. It includes protein farnesylation and geranylgeranylation, using farnesyl pyrophosphate(FPP) or geranylgeranyl pyrophosp

其他文献

An epigenetic regulatory switch controlling temperature-dependent sex determination in vertebrates

期刊

脊椎动物温度依赖开关控制性别规章环境性GuiESD

Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in tra

Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP m

期刊

视网膜神经节细胞缺血/再灌注损伤氧化应激神经胶质细胞反应缺乏症闭塞病变Epac retina ischemia retinopathy

Membrane immunoglobulin expressed by retroviral vector gene transfer mimics partial function of the

Activation of B-cells is initiated by the ligation of B-cell receptors by its cognate antigen, inducing a series of signal cascades. Understanding the molecular

期刊

逆转录病毒载体免疫球蛋白转移膜体内载体介导细胞受体信号功能B细胞BCR membrane immunoglobuUn retroviral

RGK regulation of voltage-gated calcium channels

Voltage-gated calcium channels(VGCCs) play critical roles in cardiac and skeletal muscle contractions,hormone and neurotransmitter release,as well as slower pro

期刊

电压门控钙通道神经系统GTP酶递质释放细胞增殖生理功能钙调蛋白calcium channel modulation trafficking ca

Genome re-sequencing analysis uncovers pathogenecity-related genes undergoing positive selection in

Rice blast caused by Magnaporthe oryzae(M.oryzae) is one of the most destructive diseases,which causes significant rice yield losses and affects global food sec

期刊

High-throughput development of genome-wide locus-specific informative SSR markers in wheat

<正>Dear Editor,Although simple sequence repeat(SSR)markers are not new,they are still useful and often used markers in molecular mapping and marker-assisted br

期刊

SSR标记小麦育种位点特异性全基因组高通量分子标记辅助育种多态性标记开发locus wheat informative breeding pol

Apelin activates the expression of inflammatory cytokines in microglial BV2 cells via PI-3K/Akt and

This paper aims to observe the changes of the inflammatory cytokines in microglial BV2 cells stimulated by apelin, and investigate the mechanism of inflammatory

期刊

炎性细胞因子APELIN神经胶质细胞AktERK激活MEK水apelin inflammation cytokines BV2 PI-3K

Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathologica

Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activa

期刊

血管发生内皮细胞可溶性病理性Notch眼部生理血管生成Notch signal human Delta-like4 RGD angioge

Auxin and DORNROSCHEN joint force in the shoot apex

期刊

植物生长素射击合力中央区域植物激素房间SAM干细胞

Analysis of genotypes and phenotypes in Chinese children with tuberous sclerosis complex

Tuberous sclerosis complex(TSC) is a neurocutaneous syndrome with serious clinical presentations, an autosomal dominant genetic disorder involving multiple orga

期刊

基因型儿童结节表型分析中国硬化基因突变临床表现tuberous sclerosis complex TSC1 TSC2 epilepsy ham

Protein prenylation and human diseases： a balance of protein farnesylation and geranylgeranylation

与本文相关的学术论文