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应用4种单克隆抗体和ABC技术观察22例鼻咽癌组织中B(Leu-10~+)、T(Leu-5b~+)、Th(Leu-3a~+)、Ts/c(Leu-2b~+)淋巴细胞亚群的分布特点。结果发现,各种淋巴细胞亚群在鼻咽癌实质中的分布数量显著少于间质。多数鼻咽癌病例(19/22)T细胞数量多于B细胞,Ts细胞少于Th细胞。与慢性鼻咽炎比较,鼻咽癌中的T、B、Th细胞都明显减少,提示鼻咽癌病人局部的细胞免疫与体液免疫功能都下降。
The expressions of Leu-10 ~ +, T (Leu-5b ~ +), Th (Leu-3a ~ +) and Ts / c (Leu- 2b ~ +) lymphocyte subsets distribution characteristics. The results showed that the distribution of various lymphocyte subsets in the parenchyma of NPC was significantly less than the interstitial. Most NPC cases (19/22) had more T cells than B cells and fewer Ts cells than Th cells. Compared with chronic nasopharyngitis, T, B, Th cells in nasopharyngeal carcinoma were significantly reduced, suggesting that the local cellular immunity and humoral immune function of patients with nasopharyngeal carcinoma were decreased.