论文部分内容阅读
美国辛辛那提大学病理系的研究人员近期发现,5型磷酸二酯酶(PDE5)抑制剂他达拉非可以通过特异性抑制环磷酸鸟苷(cGMP)特异性5型磷酸二酯酶A(PDE5A),并经cGMP/蛋白激酶G(PKG)信号传导通路的介导,对干细胞的存活以及增殖产生保护性作用。一次性给予间充质干细胞[(Tada)MSCs]1μmo
Researchers at the Department of Pathology at the University of Cincinnati recently found that type 5 phosphodiesterase (PDE5) inhibitor, tadalafil, could specifically inhibit cGMP-specific type 5 phosphodiesterase A (PDE5A) Mediated by the cGMP / protein kinase G (PKG) signaling pathway, has a protective effect on the survival and proliferation of stem cells. One-time administration of mesenchymal stem cells [(Tada) MSCs] 1 μmo