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实验采用大剂量生大黄长期给动物灌胃造成脾虚动物模型,以观察虫草养生酒对脾虚动物胃肠功能的影响。实验结果表明:虫草养生酒大剂量、中剂量对脾虚动物紊乱的胃肠动物均有不同程度的调整作用,表现为对脾虚动物加快的胃、肠收缩,胃排空及肠管推进率及增加的肠管重量均有减慢或减轻作用,对脾虚动物减少的胃液分泌量、胃液酸度及胃酸排出量以及降低的胃蛋白酶活性均有促进或提高作用。且对脾虚动物胃功能有改善作用,虫草养生酒中剂量比大剂量强,并可使胃的大部分功能恢复到正常水平,而对脾虚动物肠功能的改善作用,虫草养生酒大剂量比中剂量强。该实验为虫草养生酒治疗脾虚提供了胃肠功能方面的实验依据,同时为临床选用中剂量用药提供了实验依据。
The experiment used a large dose of rhubarb to gavage animals for a long time to cause spleen deficiency animal models to observe the effect of Cordyceps sinensis on gastrointestinal function of spleen deficiency animals. The experimental results showed that the high-dose and middle-dose Cordyceps sinensis wine had adjustment effects on the gastrointestinal animals with disordered spleen-deficiency animals in different degrees, manifested as accelerated gastric and intestinal contractions, gastric emptying, and intestinal propulsive rate and increase in spleen deficiency animals. Intestinal canal weight was slowed down or relieved, and the secretion of gastric juice, acidity of gastric juice, gastric acid output and decreased pepsin activity were all promoted or increased in spleen-deficient animals. In addition, the spleen deficiency animal’s stomach function is improved. Cordyceps sinensis wine has a stronger dose than large doses, and can restore most of the functions of the stomach to normal levels. The effect of improving the intestinal function of the spleen-deficiency animal is a large dose of Cordyceps sinensis. Strong dose. This experiment provided experimental basis for the treatment of spleen deficiency in the treatment of spleen deficiency with Cordyceps sinensis, and provided experimental evidence for the clinical use of medium-dose medication.