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目的探讨梅尼埃病(Meniere′s disease)患者与组织相容性白细胞抗原（histocompatibility leukocyte antigen，HLA）-II类基因DRB1等位基因的关联。方法采用聚合酶链反应-序列特异性引物（polymerase chain reaction-sequence specific primers，PCR-SSP）技术。测试60例梅尼埃病患者和85名健康人对照。结果患者组HLA-DRB1*3+5+6+8基因组集团总数高于健康对照组，相对危险性为1.99，P<0.05，患者组HLA-DRB1*09明显低于健康对照组，相对危险性为0.17，P<0.01。结论梅尼埃病患者HLA-DRB1*09显著下降，提示HLA-DRB1*09可能是梅尼埃病的保护性基因。“,”Objective To investigate the relation between histocompatibility leukocyte antigen （HLA）-class II DRB1 and Meniere′s disease in Chinese. Methods Polymerase chain reaction-sequence specific primers(PCR-SSP)technique was used. HLA-class II allele distribution were measured in 60 patients with Meniere′s disease, in comparison with those in 85 normal population. Result The results showed that the frequency of DRB1*09 allele was significantly lower in Meniere′s disease patients than in those of controls(relative risk=0.17,P<0.01). Conclusion HLA-DRB1*09 of the patients with Meniere′s disease was significant low. It implied that DRB1*09 may be a protective gene for Meniere′s disease.