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苯妥英为酶诱导剂，能增加被细胞色素P450代谢的化合物的清除作用。已发现苯妥英诱导细胞色素P450同工酶的3A类型（CYP3A）。本研究是测定健康志愿者体内苯妥英对CYP3A活性的诱导时间过程，利用测量尿中排泄的6β-羟基氢化可的松（6β-OHC）作为CYP3A在人体内诱导的选择性标记
Phenytoin is an enzyme inducer that increases the clearance of compounds that are metabolized by cytochrome P450. Phenytoin has been found to induce cytochrome P450 isoenzyme type 3A (CYP3A). This study was conducted to determine the induction time course of CYP3A activity of phenytoin in healthy volunteers by measuring urinary excretion of 6β-hydroxy-hydrocortisone (6β-OHC) as a selectable marker for CYP3A induction in humans