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Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109 (3.4％) cancer patients were included in this study.Among them,23 (21.1％) patients died in the hospital.Cancer patients,especially those with hematological malignancies (41.6％),urinary carcinoma (35.7％),malignancies of the digestive system (33.3％),gynecological malignancies (20％),and lung cancer (14.3％),had a much higher mortality than patients without cancer.A total of 19 (17.4％) cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening (NRS2002) score ≥3 (adjusted hazard ratio (HR) 11.00;95％ confidence interval (CI) 4.60-26.32;P ＜ 0.001),high-risk type (adjusted HR 18.81;95％ CI 4.21-83.93;P ＜ 0.001),tumor stage IV (adjusted HR 4.26;95％ CI 2.34-7.75;P ＜ 0.001),and recent adjuvant therapy (＜ 1 month) (adjusted HR 3.16;95％ CI 1.75-5.70;P ＜ 0.01) were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score ≥ 3,advanced tumor stage,and recent adjuvant therapy (＜ 1 month) may have high risk of mortality.