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Patients with cancer are at increased risk of severe infections.From a cohort including 3060 patients with confirmed COVID-19,109 (3.4%) cancer patients were included in this study.Among them,23 (21.1%) patients died in the hospital.Cancer patients,especially those with hematological malignancies (41.6%),urinary carcinoma (35.7%),malignancies of the digestive system (33.3%),gynecological malignancies (20%),and lung cancer (14.3%),had a much higher mortality than patients without cancer.A total of 19 (17.4%) cancer patients were infected in the hospital.The clinical characteristics of deceased cancer patients were compared with those of recovered cancer patients.Multivariate Cox regression analysis indicated that a Nutritional Risk Screening (NRS2002) score ≥3 (adjusted hazard ratio (HR) 11.00;95% confidence interval (CI) 4.60-26.32;P < 0.001),high-risk type (adjusted HR 18.81;95% CI 4.21-83.93;P < 0.001),tumor stage IV (adjusted HR 4.26;95% CI 2.34-7.75;P < 0.001),and recent adjuvant therapy (< 1 month) (adjusted HR 3.16;95% CI 1.75-5.70;P < 0.01) were independent risk factors for in-hospital death after adjusting for age,comorbidities,D-dimer,and lymphocyte count.In conclusion,cancer patients showed a higher risk of COVID-19 infection with a poorer prognosis than patients without cancer.Cancer patients with high-risk tumor,NRS2002 score ≥ 3,advanced tumor stage,and recent adjuvant therapy (< 1 month) may have high risk of mortality.